PML targeting eradicates quiescent leukaemia-initiating cells

PML targeting eradicates quiescent leukaemia-initiating cells

Nature 453, 1072 (2008). doi:10.1038/nature07016

Authors: Keisuke Ito, Rosa Bernardi, Alessandro Morotti, Sahoko Matsuoka, Giuseppe Saglio, Yasuo Ikeda, Jacalyn Rosenblatt, David E. Avigan, Julie Teruya-Feldstein
& Pier Paolo Pandolfi

The existence of a small population of ‘cancer-initiating cells’ responsible for tumour maintenance has been firmly demonstrated in leukaemia. This concept is currently being tested in solid tumours. Leukaemia-initiating cells, particularly those that are in a quiescent state, are thought to be resistant to chemotherapy